Rachel J. Boyd

Proteomic identification and validation of novel neuronal EV-based markers for Alzheimers disease biomarker discovery

The paper identifies and validates novel neuronal EV surface markers, CNTNAP2 and STX1B, for Alzheimer's disease biomarker discovery through proteomic analysis of EVs from hiPSC-derived neurons and human brain.

Neuronal titration of Snca via enhancer disruption mitigates disease onset in a Parkinson's disease mouse model

This study shows that disrupting a Snca enhancer in mice reduces Snca expression and protects against Parkinson's disease pathology and motor impairments.

Proof of concept study deploying CRISPR inhibition and activation opens new avenues for systematic biological exploration in zebrafish.

This paper demonstrates the use of CRISPRi/a in zebrafish to modulate gene expression and study gene function in pigmentary and growth phenotypes.

A Functional Schizophrenia-associated genetic variant near the TSNARE1 and ADGRB1 genes.

The paper tests a schizophrenia-associated variant near TSNARE1 and ADGRB1 for functional effects, showing allele-specific transcriptional differences and pathway enrichment in synaptic processes.

Evaluating the mouse neural precursor line, SN4741, as a suitable proxy for midbrain dopaminergic neurons

This study evaluates the mouse neural precursor cell line SN4741 as a proxy for midbrain dopaminergic neurons using genomic techniques and finds it lacks key dopaminergic markers and chromatin features.