Han Seok Ko

This study shows that disrupting a Snca enhancer in mice reduces Snca expression and protects against Parkinson's disease pathology and motor impairments.

This study identifies microglial Lag3 as a key receptor linking extracellular α-synuclein PFF recognition to neurotoxic astrocyte conversion and dopaminergic neurodegeneration.

This study evaluates G1899, an American ginseng extract, showing it reduces neuroinflammation, improves cognitive function, and clears amyloid-beta in Alzheimer's disease models.

This paper identifies NOD2/RIPK2 signaling as a key driver of neuroinflammation in Parkinson's disease, showing that pathological α-synuclein activates this pathway in microglia, leading to neurodegeneration and that targeting NOD2 or RIPK2 protects dopamine neurons.

This study investigates the effects of Gba1 E326K mutation in mice, showing increased microglia activation, neuroinflammation, and dopaminergic neurodegeneration.

The paper identifies complement and coagulation cascade pathways as significantly altered in two Parkinson's disease mouse models through proteome analysis.

The paper identifies Aplp1 and its complex with Lag3 as facilitators of pathologic alpha-synuclein transmission and toxicity, showing that disrupting this complex prevents neurodegeneration.