Sarah A. McClymont

The paper identifies Nodal/Smad2 signaling as essential for sustaining embryonic diapause by repressing Pparg-mediated lipid metabolism.

This study shows that disrupting a Snca enhancer in mice reduces Snca expression and protects against Parkinson's disease pathology and motor impairments.

This study evaluates the mouse neural precursor cell line SN4741 as a proxy for midbrain dopaminergic neurons using genomic techniques and finds it lacks key dopaminergic markers and chromatin features.

The paper identifies Parkinson's risk variants in a SNCA enhancer by analyzing open chromatin in mouse dopamine neurons and validates their function in zebrafish and mice.

The paper uses single-cell RNA-seq to identify candidate genes for sporadic Parkinson’s disease by comparing DA neuron subpopulations and integrating with GWAS data.