Mitochondrial Transplantation promotes protective effector and memory CD4+ T cell response during Mycobacterium tuberculosis infection and diminishes exhaustion and senescence in elderly CD4+ T cells
C. A. Headley, s. Guatam, A. M. Olmo-Fontanez, A. Garcia-Vilanova, V. Dwivedi, A. A. Schami, S. Weintraub, P. S. Tsao, J. B. Torrelles, J. Turner
This study shows mitochondrial transplantation enhances CD4+ T cell function in elderly individuals and mice infected with Mycobacterium tuberculosis by reducing exhaustion and senescence.
bioRxiv · Jan 24, 2024 · PreprintImmunology