Ketones facilitate transcriptional resolution of secondary DNA structures in premature aging
M. A. Petr, L. M. Carmona-Marin, T. Tulika, S. Kristensen, S. Reves, D. Bakula, G. Keijzers, B. Osborne, S. J. Mitchell, S. Hamilton, J. Kato, I. Alfaras, A. A. Teklu, I. Heckenbach, J. Madsen, , M. Scheibye-Knudsen
This study shows that ketones like beta-hydroxybutyrate reduce premature aging features in Cockayne syndrome models by enhancing transcriptional readthrough of DNA secondary structures through histone acetylation.
bioRxiv · Mar 8, 2022 · PreprintPhysiology