S. Hamilton

Acquired Cross-resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC paralogs

This paper identifies extrachromosomal DNA amplification of MYC paralogs as a recurrent driver of acquired cross-resistance in small cell lung cancer using patient-derived xenograft models.

RNA-induced allosteric coupling drives viral capsid assembly in bacteriophage MS2

This study shows RNA-induced allostery drives capsid assembly in bacteriophage MS2 by altering protein flexibility and dynamic coupling.

Activity-dependent subcellular compartmentalization of dendritic mitochondria structure in CA1 pyramidal neurons

This study identifies an activity-dependent molecular mechanism regulating subcellular compartmentalization of dendritic mitochondria morphology in CA1 pyramidal neurons.

Ketones facilitate transcriptional resolution of secondary DNA structures in premature aging

This study shows that ketones like beta-hydroxybutyrate reduce premature aging features in Cockayne syndrome models by enhancing transcriptional readthrough of DNA secondary structures through histone acetylation.

TREM2+ and interstitial macrophages orchestrate airway inflammation in SARS-CoV-2 infection in rhesus macaques

This study identifies two macrophage populations driving inflammation in the lower airway during SARS-CoV-2 infection in rhesus macaques and shows baricitinib effectively reduces their influx and cytokine production.

The meta-gut: Hippo inputs lead to community coalescence of animal and environmental microbiomes.

The paper introduces the concept of the meta-gut, showing that hippo gut microbiomes persist in their excreted waste and influence aquatic microbial communities and biogeochemistry.

Macrophages drive the inflammatory phase in experimental osteoarthritis

This study shows macrophages drive inflammation in early experimental osteoarthritis by expanding and altering their gene expression in mouse models.