Allosteric regulation of Thioesterase Superfamily Member 1 by free fatty acids and lysophosphatidylcholine
M. C. Tillman, N. Imai, Y. Li, M. Khadka, C. D. Okafor, P. Juneja, A. Adhiyaman, S. J. Hagen, D. E. Cohen, E. A. Ortlund
This study identifies the StarD domain of Them1 as a lipid sensor that allosterically regulates its activity and localization in response to fatty acids and lysophosphatidylcholine.
bioRxiv · Feb 18, 2020 · PreprintBiochemistry