Author

D. E. Cohen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 2 Research Focus:metabolism & bioenergetics· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

E. A. Ortlund· 3 shared M. C. Tillman· 3 shared N. Imai· 2 shared S. J. Hagen· 2 shared Y. Li· 2 shared A. Adhiyaman· 1 shared A. F. Stenzel· 1 shared A. W. Ashbrook· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersPharmacology & Toxicology

E. A. Ortlund

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

High-throughput screening identifies small molecule inhibitors of thioesterase superfamily member 1: Implications for the management of non-alcoholic fatty liver disease

C. S. Krumm, L. Ramos-Espiritu, R. S. Landzberg, C. Adura, X. Liu, M. Acuna, Y. Xie, X. Xu, M. C. Tillman, Y. Li, F. Glickman, E. A. Ortlund, J. D. Ginn, D. E. Cohen

This study identifies small molecule inhibitors of Them1, showing they enhance fatty acid oxidation and reduce glucose production in liver cells, suggesting therapeutic potential for NAFLD.

Molecular Metabolism · Dec 1, 2023Peer-reviewedPharmacology & Toxicology

Human hepatocyte PNPLA3 148M exacerbates rapid non-alcoholic steatohepatitis development in chimeric mice

M. Kabbani, E. Michailidis, S. Steensels, C. G. Fulmer, J. M. Luna, J. Le Pen, M. Tardelli, B. Razooky, I. Ricardo-Lax, C. Zou, B. Zeck, A. F. Stenzel, C. Quirk, L. Foquet, A. W. Ashbrook, , Y. P. de Jong

This study shows that the PNPLA3 148M variant in human hepatocytes worsens non-alcoholic steatohepatitis in chimeric mice on a hypercaloric diet.

bioRxiv · Nov 19, 2020 · PreprintPathology

Allosteric regulation of Thioesterase Superfamily Member 1 by free fatty acids and lysophosphatidylcholine

M. C. Tillman, N. Imai, Y. Li, M. Khadka, C. D. Okafor, P. Juneja, A. Adhiyaman, S. J. Hagen, D. E. Cohen, E. A. Ortlund

This study identifies the StarD domain of Them1 as a lipid sensor that allosterically regulates its activity and localization in response to fatty acids and lysophosphatidylcholine.

bioRxiv · Feb 18, 2020 · PreprintBiochemistry

Thioesterase Superfamily Member 1 Undergoes Stimulus-coupled Reorganization to Regulate Metabolism

Y. Li, N. Imai, S. Goyal, H. T. Nicholls, T. I. Krisko, M. Baqai, L.-H. Ang, M. C. Tillman, E. A. Ortlund, D. E. Cohen, S. J. Hagen

This paper shows that Them1 undergoes conformational changes in response to stimuli, forming biomolecular condensates that regulate fatty acid oxidation and thermogenesis.

bioRxiv · Feb 18, 2020Cell Biology