S. J. Hagen

This study uses patient-derived enteroids to model Microvillus Inclusion Disease and identifies therapeutic strategies targeting Notch signaling and chloride channels.

The paper uses two-photon microscopy to study spatial distribution of comX expression in S. mutans biofilms, finding that competence-signaling peptides diffuse efficiently and do not create clustered microenvironments.

This study identifies the StarD domain of Them1 as a lipid sensor that allosterically regulates its activity and localization in response to fatty acids and lysophosphatidylcholine.

This paper shows that Them1 undergoes conformational changes in response to stimuli, forming biomolecular condensates that regulate fatty acid oxidation and thermogenesis.

This study identifies environmental triggers for lrgA expression in Streptococcus mutans using microfluidics and single-cell imaging, finding that extracellular pyruvate, glucose, and oxygen regulate its activation.

This study identifies how carbohydrate source and PepO modulate bimodal comX expression in Streptococcus mutans, revealing mechanisms controlling competence development.

This study shows that S. mutans can activate comX through intracellular positive feedback loops involving ComS/XIP, independent of extracellular signals.

This study investigates how MecA/ClpCP regulates competence in S. mutans by providing threshold control and stochasticity in comY activation.

This study demonstrates that XIP from Streptococcus mutans functions as an intercellular signal, showing diffusibility and signaling without cell-to-cell contact, with cell lysis enhancing its release.