Different SUMO Paralogs Determine the Fate of WT and Mutant CFTRs: Biogenesis vs. Degradation
X. Gong, Y. Liao, A. Ahner, M. B. Larsen, X. Wang, C. Bertrand, R. A. Frizzell
This study shows that SUMO paralogs determine the fate of WT and mutant CFTRs, with PIAS4 promoting biogenesis and reducing degradation.
bioRxiv · Jun 7, 2018Cell Biology