X. Gong

Variant Surface Protein GP60 Contributes to Host Infectivity of Cryptosporidium parvum

The paper investigates the role of GP60 in Cryptosporidium parvum infectivity, finding that while GP60 is not essential, its cleavage products affect parasite growth and infection severity.

Mitochondrial fission surveillance is coupled to Caenorhabditis elegans DNA and chromosome segregation integrity

The paper identifies genes regulating mitochondrial fission in C. elegans and shows that chromosome missegregation leads to mitochondrial fission dysregulation, independent of Drp-1.

Adaptation to volumetric compression drives hepatoblastoma cells to an apoptosis-resistant and invasive phenotype

This study shows that volumetric compression in liver cancer cells leads to transcriptional reprogramming, increased invasiveness, and chemoresistance, with potential reversal via calcium signaling.

Volumetric Compression Shifts Rho GTPase Balance and Induces Mechanobiological Cell State Transition

The paper investigates how volumetric compression affects Rho GTPase balance and mechanobiological cell state transitions through physical and molecular changes.

Instant Assembly of Collagen for Scaffolding, Tissue Engineering, and Bioprinting

This paper introduces TRACE, a method for instant collagen gelation and patterning, enabling applications in biofabrication and tissue engineering.

Accurate Simulation of Coupling between Protein Secondary Structure and Liquid-Liquid Phase Separation

This paper introduces a hybrid resolution protein model (HyRes) to accurately simulate the coupling between protein secondary structure and liquid-liquid phase separation in intrinsically disordered proteins.

Coronavirus endoribonuclease nsp15 induces host cellular protein synthesis shutoff

This study shows that coronavirus nsp15 inhibits host protein synthesis and targets host mRNA, with EndoU activity essential for these effects and virus replication.

Effect of cell membrane tension on the lifetime and size of mature clathrin-coated pits and their spatial distribution

The paper investigates how membrane tension affects the size, lifetime, and spatial distribution of clathrin-coated pits during maturation.

Adaptive optical two-photon fluorescence microscopy probes cellular organization of ocular lenses in vivo

This study uses adaptive optical two-photon fluorescence microscopy to image ocular lens cellular organization in vivo, revealing novel structures and growth dynamics previously unseen in dissected lenses.

Multi-site assessment of reproducibility in high-content live cell imaging data

This study assesses reproducibility in high-content live cell imaging data across multiple sites and identifies sources of variability, showing that batch correction improves meta-analysis of perturbation experiments.

A novel cis-element enabled bacterial uptake by plant cells

The paper identifies a cis-regulatory element, PACE, critical for bacterial uptake in plant cells through its role in nodule formation and infection thread development.

Reassortment Network of Influenza A Virus

This study analyzes the reassortment network of Influenza A Virus using genome-wide data to identify reassortment events and their evolutionary implications.

Mechanoaccumulation of non-muscle myosin IIB during mitosis requires its translocation activity

This study shows that during mitosis, NMIIB mechanoaccumulation at the cell cortex requires its motor activity, not just actin-binding function, and is mediated by RhoA and ROCK signaling.

A CCaMK/Cyclops response element in the promoter of L. japonicus Calcium-Binding Protein 1 (CBP1) mediates transcriptional activation in root symbioses

The paper identifies a CCaMK/Cyclops response element in the CBP1 promoter that mediates transcriptional activation in both arbuscular mycorrhiza and root nodule symbioses.

Local temporal Rac1-GTP nadirs and peaks restrict cell protrusions and retractions

This study shows Rac1-GTP peaks and nadirs regulate protrusion and retraction lifetimes in fibrosarcoma cells by controlling traction forces.

Structural basis of substrate recognition and translocation by human ABCA4

This study presents cryo-EM structures of human ABCA4 in different states, revealing substrate recognition and translocation mechanisms.

Inhibition of Anti-viral Stress Granule Formation by infectious bronchitis virus endoribonuclease nsp15 Ensures Efficient Virus Replication

This study shows that IBV uses nsp15 to inhibit stress granule formation, thereby evading antiviral responses and promoting viral replication.

Protein family content uncovers lineage relationships and bacterial pathway maintenance mechanisms in DPANN archaea

The paper uses protein family content to analyze lineage relationships and pathway maintenance mechanisms in DPANN archaea, revealing metabolic and symbiotic traits.

An Organotypic Mammary Duct Model Capturing Distinct Events of DCIS Progression

This paper develops an organotypic mammary duct model to study DCIS progression, showing it can recapitulate different stages of breast cancer progression and respond to matrix stiffness.

Growth of tumor emboli within a vessel model reveals dependence on the magnitude of mechanical constraint.

This study shows that tumor emboli grow more in stiff vessel-like environments due to mechanical constraints, leading to increased tumor burden.

The genome assembly and annotation of Magnolia biondii Pamp., a phylogenetically, economically, and medicinally important ornamental tree species

This paper presents a chromosome-level genome assembly and annotation of Magnolia biondii, revealing insights into its evolutionary history and gene function.

Mouse thy1-positive spermatogonia suppress the proliferation of spermatogonial stem cells by Extracellular vesicles in vitro

This study shows that extracellular vesicles from thy1-positive spermatogonia suppress the proliferation of spermatogonial stem cells in vitro without inducing apoptosis.

Susceptibility trends of zoliflodacin against multidrug-resistant Neisseria gonorrhoeae clinical isolates in NanJing, China (2014-2018)

This study tracks zoliflodacin susceptibility trends in Neisseria gonorrhoeae isolates from 2014-2018, showing increasing MICs and resistance mutations, while maintaining overall susceptibility.

Rapid development of an inactivated vaccine for SARS-CoV-2

A purified inactivated SARS-CoV-2 vaccine candidate (PiCoVacc) induces neutralizing antibodies in animals and shows safety and partial to complete protection against SARS-CoV-2 strains.

Effects of carbon-based additive and ventilation rate on nitrogen loss and microbial community during chicken manure composting

The paper investigates how carbon-based additives and ventilation rates affect nitrogen loss and microbial communities in chicken manure composting, finding that woody peat reduces nitrogen loss more effectively than other additives.

Association between ocular biometrical parameters and diabetic retinopathy in Chinese adults with type 2 diabetes mellitus

This study examines the relationship between ocular biometrical parameters and diabetic retinopathy in Chinese adults with type 2 diabetes, finding associations between axial length, lens power, and AL/CR ratio with DR risk.

The influence of insulin therapy on measurements of optical coherence tomography parameters in diabetic patients without retinopathy

This study examines the effect of insulin therapy on OCT/A measurements in diabetic patients without retinopathy, finding thinner MCT and lower PVD in insulin users.

The genomic landscape of intrinsic and acquired resistance to cyclin-dependent kinase 4/6 inhibitors in patients with hormone receptor positive metastatic breast cancer

The paper identifies eight resistance mechanisms to CDK4/6 inhibitors in HR+ breast cancer, present in 80% of resistant tumors, with potential therapeutic strategies.

Rapid fabrication of collagen bundles mimicking tumor-associated collagen signatures

This study develops a method to create collagen bundles that mimic tumor-associated collagen structures, showing enhanced cancer cell migration and invasion in vitro.

Effects of food restriction on body mass, energy metabolism and thermogenesis in a tree shrew (Tupaia belangeri)

This study examines how food restriction affects tree shrews' body mass, energy metabolism, and thermogenesis under different temperatures and food intake levels.