Heart-on-a-chip model of immune-induced cardiac dysfunction reveals the involvement of free mitochondrial DNA and therapeutic effects of endothelial exosomes
X. Z. Lu, N. Rafatian, Y. Zhao, K. T. Wagner, E. L. Beroncal, B. Li, C. Lee, J. Chen, E. Churcher, D. Vosoughi, Y. Wang, A. Baker, U. Trahtemberg, B. Li, A. Pierro, , M. Radisic
This paper develops a heart-on-a-chip model to study immune-induced cardiac dysfunction, identifying mitochondrial DNA as a key factor and showing therapeutic potential of endothelial exosomes.
bioRxiv · Aug 9, 2023 · PreprintBioengineering