Pentamycin biosynthesis in Philippine Streptomyces sp. S816: Cytochrome P450-catalysed installation of the C-14 hydroxyl group
S. Zhou, L. Song, J. Masschelein, F. A. Sumang, I. A. Papa, T. O. Zulaybar, A. B. Custodio, D. Zabala, E. P. Alcantara, E. L. de los Santos, G. L. Challis
The paper identifies Streptomyces sp. S816 as a pentamycin producer and shows that the ptnJ gene encodes a cytochrome P450 responsible for converting filipin III to pentamycin.
bioRxiv · Apr 10, 2019Biochemistry