Author

G. L. Challis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:bacteria (other)· 4 Research Focus:gene regulatory network inference· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Assay:structural biology· 2 Assay:whole-genome sequencing· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

M. Jenner· 4 shared A. J. Mullins· 2 shared C. D. Fage· 2 shared D. Zabala· 2 shared E. Mahenthiralingam· 2 shared G. Webster· 2 shared L. M. Alkhalaf· 2 shared L. Song· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersBiochemistry

M. Jenner

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Author profile →

7 papers

Recent·Most cited

Antibiotic skeletal diversification via differential enoylreductase recruitment and module iteration in trans-acyltransferase polyketide synthases

X. Jian, F. Pang, C. Hobson, M. Jenner, L. M. Alkhalaf, G. L. Challis

The paper investigates how structural diversity in polyketide antibiotics arises through differential enoylreductase recruitment and module iteration in trans-acyltransferase polyketide synthases.

bioRxiv · Nov 30, 2023 · PreprintBiochemistry

Molecular basis for short-chain thioester hydrolysis by acyl hydrolase domains in trans-acyltransferase polyketide synthases

C. D. Fage, M. Passmore, B. P. Tatman, H. G. Smith, X. Jian, U. C. Dissanayake, G. A. Cisneros, G. L. Challis, J. R. Lewandowski, M. Jenner

The paper solves the structure of an acyl hydrolase (AH) domain and investigates its mechanism for hydrolyzing short-chain thioesters on acyl carrier protein (ACP) domains in trans-AT PKSs.

bioRxiv · Aug 11, 2023 · PreprintBiochemistry

Discovery and Biosynthesis of Persiathiacins: Unusual Polyglycosylated Thiopeptides Active against Multi-drug resistant Tuberculosis

Y. Dashti, F. Mohammadipanah, M. J. Belousoff, A. Vocat, D. Zabala, C. D. Fage, I. Romero-Canelon, B. Bunk, C. Sproer, J. Overmann, S. T. Cole, G. L. Challis

This study discovers two novel polyglycosylated thiopeptides, persiathiacins A and B, active against drug-resistant tuberculosis and identifies their biosynthetic gene cluster.

bioRxiv · Oct 24, 2021 · PreprintMicrobiology

Exploration of polyyne biosynthetic gene cluster diversity in bacteria leads to the discovery of the Pseudomonas polyyne protegencin

A. J. Mullins, G. Webster, H. J. Kim, J. Zhao, Y. D. Petrova, C. E. Ramming, M. Jenner, J. A. H. Murray, T. R. Connor, C. Hertweck, G. L. Challis, E. Mahenthiralingam

The paper explores polyyne biosynthetic gene clusters in bacteria, identifies a conserved seven-gene cassette in Pseudomonas, and discovers the metabolite protegencin.

bioRxiv · Mar 5, 2021Microbiology

Structural basis for control of antibiotic production by bacterial hormones

S. Zhou, H. Bhukya, N. Malet, P. J. Harrison, D. Rea, M. J. Belousoff, H. Venugopal, P. K. Sydor, K. M. Styles, L. Song, M. J. Cryle, L. M. Alkhalaf, V. Fülöp, G. L. Challis, C. Corre

This study determines the structural basis for hormone-controlled antibiotic production in Actinobacteria by solving the X-ray structure of an MmfR-AHFCA complex and elucidating DNA release mechanisms.

bioRxiv · May 2, 2020Biochemistry

Kill and cure: genomic phylogeny and bioactivity of a diverse collection of Burkholderia gladioli bacteria capable of pathogenic and beneficial lifestyles

C. Jones, G. Webster, A. J. Mullins, M. Jenner, M. J. Bull, Y. Dashti, T. Spilker, J. Parkhill, T. R. Connor, J. J. LiPuma, G. L. Challis, E. Mahenthiralingam

This study examines the genomic phylogeny and bioactivity of 206 Burkholderia gladioli strains, identifying toxin-producing clades and potential therapeutic strategies for CF-related infections.

bioRxiv · Apr 9, 2020Microbiology

Pentamycin biosynthesis in Philippine Streptomyces sp. S816: Cytochrome P450-catalysed installation of the C-14 hydroxyl group

S. Zhou, L. Song, J. Masschelein, F. A. Sumang, I. A. Papa, T. O. Zulaybar, A. B. Custodio, D. Zabala, E. P. Alcantara, E. L. de los Santos, G. L. Challis

The paper identifies Streptomyces sp. S816 as a pentamycin producer and shows that the ptnJ gene encodes a cytochrome P450 responsible for converting filipin III to pentamycin.

bioRxiv · Apr 10, 2019Biochemistry