HIV-1 Vpr Induces Degradation of Nucleolar Protein CCDC137 as a Consequence of Cell Cycle Arrest
L. J. Martins, A. B. DePaula-Silva, V. Planelles
The paper confirms that HIV-1 Vpr induces degradation of CCDC137 via the CUL4ADDB1.DCAF1 E3 ligase complex, but shows this degradation is a consequence, not a trigger, of G2/M cell cycle arrest.
bioRxiv · Mar 16, 2021 · PreprintMicrobiology