Author

V. Planelles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 8 Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 6 Research Focus:cell type annotation· 5 Assay:bulk RNA-seq· 4 Research Focus:cell signaling & trafficking· 4 Assay:proteomics· 4 Research Focus:differential expression· 2

Frequent Co-Authors

A. M. Spivak· 2 shared E. S. C. P. Williams· 2 shared E. T. Larragoite· 2 shared L. J. Martins· 2 shared L. R. Barrows· 2 shared T. Hanley· 2 shared Y. Zheng· 2 shared A. B. DePaula-Silva· 1 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersMicrobiology

A. M. Spivak

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Author profile →

9 papers

Recent·Most cited

Reduced Monocyte Proportions and Responsiveness in Convalescent COVID-19 Patients

E. Ravkov, E. S. C. P. Williams, M. Elgort, A. Spivak, A. P. Barker, V. Planelles, J. Delgado, L. Lin, T. Hanley

This study shows that SARS-CoV-2 infection reduces monocyte subsets and their functional responses in convalescent patients compared to uninfected controls.

bioRxiv · Oct 25, 2023Immunology

Histone deacetylase inhibition reduces deleterious cytokine release induced by ingenol stimulation

E. T. Larragoite, R. A. Nell, L. J. Martins, L. R. Barrows, V. Planelles, A. M. Spivak

This study identifies HDAC inhibitors that reduce pro-inflammatory cytokine secretion during HIV-1 latency reversal without reactivating the virus.

bioRxiv · Sep 24, 2021Microbiology

ADAP1 promotes latent HIV-1 reactivation by selectively tuning a T cell signaling-transcriptional axis

N. G. Ramirez, J. Lee, Y. Zheng, L. Li, B. Dennis, D. Chen, A. Challa, V. Planelles, K. D. Westover, N. Alto, I. D'Orso

This study identifies ADAP1 as a factor that enhances T cell signaling and promotes HIV-1 reactivation by modulating the ERK-AP-1 axis.

bioRxiv · Jul 26, 2021 · PreprintMicrobiology

HIV-1 provirus transcription and translation in macrophages differs from macrophages containing pre-integrated cDNA complexes and requires E2F transcriptional programs

A. L. Lim, P. Moos, C. D. Pond, E. C. Larson, L. L. Martins, M. A. Szaniawski, V. Planelles, L. R. Barrows

The paper compares HIV-1 transcription from pre-integrated cDNA and integrated provirus in macrophages using scRNA-seq, finding that provirus transcription correlates with viral protein production and E2F transcriptional programs.

bioRxiv · Apr 21, 2021Microbiology

HIV-1 Vpr Induces Degradation of Nucleolar Protein CCDC137 as a Consequence of Cell Cycle Arrest

L. J. Martins, A. B. DePaula-Silva, V. Planelles

The paper confirms that HIV-1 Vpr induces degradation of CCDC137 via the CUL4ADDB1.DCAF1 E3 ligase complex, but shows this degradation is a consequence, not a trigger, of G2/M cell cycle arrest.

bioRxiv · Mar 16, 2021 · PreprintMicrobiology

Neutralization Assay with SARS-CoV-1 and SARS-CoV-2 Spike Pseudotyped Murine Leukemia Virions

Y. Zheng, E. T. Larragoite, J. Lama, I. Cisneros, J. C. Delgado, P. Slev, J. Rychert, E. A. Innis, E. S. C. P. Williams, M. Coiras, M. Rondina, A. M. Spivak, V. Planelles

The paper develops a neutralization assay using SARS-CoV-1 and SARS-CoV-2 spike pseudotyped murine leukemia virions to measure neutralizing antibody titers in serum or plasma.

bioRxiv · Jul 17, 2020Microbiology

Vpr R36W and R77Q Mutations Alter HIV-1 Replication and Cytotoxicity in T Lymphocytes

A. Solis-Leal, D. C. Karlinsey, J. B. Lopez, V. Planelles, B. D. Poole, B. K. Berges

This study examines how Vpr mutations R36W and R77Q affect HIV-1 replication and cytotoxicity in T lymphocytes, linking them to rapid and slow AIDS progression phenotypes.

bioRxiv · May 26, 2020 · PreprintMicrobiology

Interactions with Commensal and Pathogenic Bacteria Induce HIV-1 Latency in Macrophages through Altered Transcription Factor Recruitment to the LTR

G. Viglianti, V. Planelles, T. Hanley

This paper shows that commensal and pathogenic bacteria induce HIV-1 latency in macrophages by altering transcription factor recruitment to the LTR through TLR4 and TRIF signaling.

bioRxiv · May 18, 2020Microbiology

Stable integrant-specific differences in bimodal HIV-1 expression patterns revealed by high-throughput analysis

D. F. Read, E. Atindaana, K. Pyaram, F. Yang, S. Emery, A. Cheong, K. R. Nakama, E. Larragoite, E. Battivelli, E. Verdin, V. Planelles, C.-H. Chang, A. Telesnitsky, J. M. Kidd

The paper tracks HIV-1 proviral clones over time in polyclonal populations, revealing stable, clone-specific expression patterns and clonal expansion dynamics independent of cell-type or metabolic factors.

PLOS Pathogens · Oct 4, 2019Peer-reviewedMicrobiology