LKB1 inactivation modulates chromatin accessibility to drive metastatic progression
S. E. Pierce, J. M. Granja, M. R. Corces, J. J. Brady, M. K. Tsai, A. B. Pierce, R. Tang, P. Chu, D. M. Feldser, H. Chang, M. C. Bassik, W. J. Greenleaf, M. M. Winslow
This study shows that LKB1 inactivation alters chromatin accessibility, promoting metastatic progression in lung cancer through SOX17 activation.
bioRxiv · Mar 29, 2021Cancer Biology