Author

J. M. Granja

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:scRNA-seq· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CITE-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

H. Y. Chang· 2 shared K. E. Yost· 2 shared M. R. Corces· 2 shared A. B. Pierce· 1 shared A. L. S. Chang· 1 shared A. T. Satpathy· 1 shared C. Curtis· 1 shared C. V. Duffy· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

H. Y. Chang

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Author profile →

3 papers

Recent·Most cited

LKB1 inactivation modulates chromatin accessibility to drive metastatic progression

S. E. Pierce, J. M. Granja, M. R. Corces, J. J. Brady, M. K. Tsai, A. B. Pierce, R. Tang, P. Chu, D. M. Feldser, H. Chang, M. C. Bassik, W. J. Greenleaf, M. M. Winslow

This study shows that LKB1 inactivation alters chromatin accessibility, promoting metastatic progression in lung cancer through SOX17 activation.

bioRxiv · Mar 29, 2021Cancer Biology

EcDNA hubs drive cooperative intermolecular oncogene expression

K. L. Hung, K. E. Yost, L. Xie, S. Wu, J. T. Lange, C. V. Duffy, K. Kraft, J. Tang, Q. Shi, J. C. Rose, M. R. Corces, J. M. Granja, R. Li, U. Rajkumar, R. Tjian, , H. Y. Chang

The paper identifies ecDNA hubs as nuclear structures that drive cooperative oncogene expression through intermolecular enhancer-promoter interactions and shows BET inhibitors can disrupt these hubs and kill cancer cells.

bioRxiv · Nov 19, 2020Cancer Biology

Clonal replacement of tumor-specific T cells following PD-1 blockade

K. E. Yost, A. T. Satpathy, D. K. Wells, Y. Qi, C. Wang, R. Kageyama, K. McNamara, J. M. Granja, K. Y. Sarin, R. A. Brown, R. K. Gupta, C. Curtis, S. L. Bucktrout, M. M. Davis, A. L. S. Chang, H. Y. Chang

This study tracks T cell clonal dynamics before and after PD-1 blockade in cancer patients, finding that new T cell clones, not pre-existing ones, expand in response to treatment.

bioRxiv · May 24, 2019Immunology