Author

J. J. Brady

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

A. B. Pierce· 1 shared C. Watson· 1 shared D. M. Feldser· 1 shared G. J. Gatto· 1 shared H. Chang· 1 shared J. M. Granja· 1 shared M. C. Bassik· 1 shared M. K. Tsai· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperCancer Biology

A. B. Pierce

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Author profile →

2 papers

Recent·Most cited

Biochemical and functional characterization of the p.A165T missense variant of mitochondrial amidoxime-reducing component 1 in HepG2 cells

W. Hou, C. Watson, T. Cecconie, M. N. Bolaki, J. J. Brady, Q. Lu, G. J. Gatto, T. A. Day

This study characterizes the p.A165T missense variant of mARC1 in HepG2 cells, showing mislocalization, reduced stability, and impaired enzymatic function, which may explain its protective effect in liver disease.

bioRxiv · Oct 18, 2023 · PreprintCell Biology

LKB1 inactivation modulates chromatin accessibility to drive metastatic progression

S. E. Pierce, J. M. Granja, M. R. Corces, J. J. Brady, M. K. Tsai, A. B. Pierce, R. Tang, P. Chu, D. M. Feldser, H. Chang, M. C. Bassik, W. J. Greenleaf, M. M. Winslow

This study shows that LKB1 inactivation alters chromatin accessibility, promoting metastatic progression in lung cancer through SOX17 activation.

bioRxiv · Mar 29, 2021Cancer Biology