PROTAC-mediated Degradation of HIV-1 Nef Efficiently Restores Cell-surface CD4 and MHC-I Expression and Blocks HIV-1 Replication
L. A. Emert-Sedlak, C. M. Tice, H. Shi, J. J. Alvarado, S. T. Shu, A. B. Reitz, T. E. Smithgall
This study develops PROTACs to degrade HIV-1 Nef, restoring CD4 and MHC-I expression and inhibiting HIV-1 replication in T cells and PBMCs.
bioRxiv · Aug 14, 2023Pharmacology & Toxicology