Cell-free assays reveal that the HIV-1 capsid protects reverse transcripts from cGAS
T. M. Scott, L. M. Arnold, J. A. Powers, D. A. McCann, A. B. Rowe, D. E. Christensen, M. J. Pereira, W. Zhou, R. M. Torrez, J. H. Iwasa, P. J. Kranzusch, W. I. Sundquist, J. S. Johnson
The paper shows that HIV-1 capsids protect reverse-transcribed DNA from cGAS detection, and that disrupting the capsid enhances cGAS activity.
bioRxiv · Apr 22, 2024Microbiology