W. I. Sundquist

The Calpain-7 protease functions together with the ESCRT-III protein IST1 within the midbody to regulate the timing and completion of abscission

This study shows that CAPN7 interacts with IST1 at midbodies to regulate abscission and the NoCut checkpoint through proteolytic activity.

HIV-1 preintegration complex preferentially integrates the viral DNA into nucleosomes containing trimethylated histone 3-lysine 36 modification

This study identifies that HIV-1 preintegration complex preferentially integrates viral DNA into nucleosomes with H3K36me3 modification and linker DNA.

Comprehensive analysis of the human ESCRT-III-MIT domain interactome reveals new cofactors for cytokinetic abscission

This study maps the human MIT-ESCRT-III interactome, identifies new cofactors for cytokinetic abscission, and reveals their functional roles in abscission and regulation.

Recurrent Emergence of an Antiviral Defense through Repeated Retrotransposition and Truncation of CHMP3

This study identifies retroCHMP3 as an antiviral defense mechanism that inhibits HIV-1 budding by disrupting the ESCRT pathway, showing distinct evolutionary paths in New World monkeys and mice.

Abscission Checkpoint Bodies Reveal a New Facet of Abscission Checkpoint Control

The paper identifies cytoplasmic abscission checkpoint bodies (ACBs) that regulate cytokinetic abscission by delaying midbody machinery recruitment.

RetroCHMP3 Blocks Budding of Enveloped Viruses Without Blocking Cytokinesis

The paper identifies duplicated and truncated CHMP3 variants in New World monkeys and mice that inhibit enveloped virus budding without affecting essential cellular ESCRT functions.

Vaccinia virus hijacks ESCRT-mediated multivesicular body formation for virus egress

This study identifies ESCRT-III and VPS4 as essential for vaccinia virus packaging into multivesicular bodies, revealing an alternative pathway for virus egress.

Membrane constriction and thinning by sequential ESCRT-III polymerization

This study determines the structures of ESCRT-III filaments to show how sequential polymerization by CHMP1B and IST1 drives membrane tubulation, constriction, and thinning.

A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability

This paper identifies a cancer-associated polymorphism in CHMP4C that disrupts the abscission checkpoint, leading to genome instability and increased cancer risk.

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells

This study identifies LEM2 and CHMP7 as conserved factors that recruit ESCRT-III proteins to the nuclear envelope during closure in fission yeast and human cells.