P. J. Kranzusch

TIR domains produce histidine-ADPR conjugates as immune signaling molecules in bacteria

The paper identifies His-ADPR as a novel TIR-derived immune signaling molecule in bacteria, showing its role in phage defense and structural basis for recognition.

Bacterial SEAL domains undergo autoproteolysis and function in regulated intramembrane proteolysis

This paper identifies bacterial SEA-like (SEAL) domains that undergo autoproteolysis and function in mechanotransduction, similar to eukaryotic SEA domains.

CARD-like domains mediate anti-phage defense in bacterial gasdermin systems

This study identifies CARD-like domains in bacterial defense systems that activate gasdermin-mediated cell death against phage infection.

Convergent mutations in phage virion assembly proteins enable evasion of Type I CBASS immunity

The paper identifies mutations in phage virion assembly proteins that enable evasion of Type I CBASS immunity by altering infection kinetics.

A novel virus-induced cyclic dinucleotide, 2'3'-c-di-GMP, mediates STING-dependent antiviral immunity in Drosophila

Structure and assembly of a bacterial gasdermin pore

This study determines the structure of a bacterial gasdermin pore and reveals a conserved mechanism of pore assembly and membrane targeting.

RNase L activating 2'-5' oligoadenlyates bind ABCF1, -3 and Decr-1

The paper identifies ABCF1, ABCF3, and Decr1 as 2'-5' OA binding proteins, showing evolutionary conservation and species-specific interactions, but finds no strong antiviral functions or translation regulation.

Cryo-EM structure of the RADAR supramolecular anti-phage defense complex

The paper determines the cryo-EM structure of the RADAR complex, showing RdrB targets mononucleotides and catalyzes ATP-to-ITP conversion to limit phage replication.

Structural homology screens reveal poxvirus-encoded proteins impacting inflammasome-mediated defenses

The paper identifies poxvirus-encoded proteins that impact inflammasome-mediated defenses through structural homology screens.

cGLRs are a diverse family of pattern recognition receptors in animal innate immunity

The paper identifies cGLRs as a widespread family of pattern recognition receptors in animal innate immunity and elucidates their conserved signaling mechanisms.

Viruses inhibit TIR gcADPR signaling to overcome bacterial defense

The paper identifies Tad1 proteins as inhibitors of TIR-domain signaling in bacterial antiphage systems, revealing gcADPR as the immune signaling molecule and its sequestration by Tad1.

Three functionally distinct classes of cGAS proteins in nature revealed by self-DNA-induced interferon responses

The paper identifies three functional classes of cGAS proteins in mammals based on their self-DNA reactivity and interferon response mechanisms.

Sequential action of a tRNA base editor in conversion of cytidine to pseudouridine

The paper characterizes a sequential C-to-U and U-to-Ψ RNA editing process in Vibrio cholerae tRNA mediated by TrcP, revealing its role in coupling tRNA modification states to iron availability.

Bacterial gasdermins reveal an ancient mechanism of cell death

This study identifies bacterial gasdermin homologs that execute prokaryotic cell death via caspase-like protease activation, revealing an ancient mechanism of regulated cell death shared with animals.

Varicella-Zoster Virus ORF9 Is an Antagonist of the DNA Sensor cGAS

This study identifies ORF9 as a VZV protein that inhibits the cGAS/STING pathway, reducing type I IFN production during infection.

Structure and mechanism of a cyclic trinucleotide-activated bacterial endonuclease mediating bacteriophage immunity

The paper characterizes NucC, a bacterial endonuclease activated by cyclic tri-AMP to mediate bacteriophage immunity through DNA cleavage or cell death.

cGAMP signaling controls a transient surface-associated lifestyle

The paper shows that the GacA enzyme in Geobacter sulfurreducens specifically regulates cGAMP levels to control metal reduction genes, despite in vitro promiscuity, through a kinetic model and structural analysis.