G-Quadruplexes Act as Sequence Dependent Chaperones via Protein Oligomerization
A. Begeman, T. J. Litberg, J. Bourne, Z. Xuan, S. Horowitz
This study shows nucleic acid sequences, particularly G-quadruplexes, can act as chaperones by oligomerizing with proteins to prevent aggregation, with implications for diseases like Fragile X and ALS.
bioRxiv · Nov 21, 2019Biochemistry