Author

Z. Xuan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

J. Wu· 2 shared A. A. Hyman· 1 shared A. Begeman· 1 shared A. Patel· 1 shared C. Yang· 1 shared C. Zhou· 1 shared D. Colon-Ramos· 1 shared D. G. Shryock· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersMicrobiology

J. Wu

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Obesity modifies cell fate plasticity of Pdgfrα-expressing adipocyte progenitors to promote an aberrant mammary microenvironment

S. A. Kwende, P. Nuthalapati, J. P. Sunder Singh, S. Maity, D. Ning, D. G. Shryock, Z. Xuan, P. A. Joshi

This study identifies obesity-induced changes in PDGFRα-expressing adipocyte progenitors that promote a cancer-susceptible mammary microenvironment through EGFR-mediated pathways.

bioRxiv · Dec 28, 2023 · PreprintCell Biology

Conserved Untranslated Regions of Multipartite Viruses: Natural Markers of Novel Viral Genomic Components and Tags of Viral Evolution

S. Zhang, C. Yang, J. Wu, Y. Qiu, Z. Xuan, L. Yang, R. Liao, X. Liang, H. Yu, F. Ren, Y. Dong, X. Xie, Y. Han, D. Wu, P. L. Ramos-Gonzalez, , M. Cao

This study identifies novel viral genomic components and evolutionary patterns using conserved untranslated regions (UTRs) and UTR-backed iterative BLASTn in multipartite viruses.

bioRxiv · Jan 16, 2022Microbiology

A Novel Oncogenic Function of PRC2 Heterogeneity in Medulloblastoma

J. Yi, X. Shi, X. Zhan, R. Lu, Z. Xuan, J. Wu

This study shows that PRC2 heterogeneity in SHH medulloblastomas drives tumor growth through intrinsic and non-cell autonomous mechanisms involving IGF2.

bioRxiv · Dec 2, 2021 · PreprintCancer Biology

G-Quadruplexes Act as Sequence Dependent Chaperones via Protein Oligomerization

A. Begeman, T. J. Litberg, J. Bourne, Z. Xuan, S. Horowitz

This study shows nucleic acid sequences, particularly G-quadruplexes, can act as chaperones by oligomerizing with proteins to prevent aggregation, with implications for diseases like Fragile X and ALS.

bioRxiv · Nov 21, 2019Biochemistry

The Glycolytic Protein Phosphofructokinase Dynamically Relocalizes into Subcellular Compartments with Liquid-like Properties in vivo

S. Jang, Z. Xuan, R. C. Lagoy, L. M. Jawerth, I. Gonzalez, M. Singh, S. Prashad, H. S. Kim, A. Patel, D. R. Albrecht, A. A. Hyman, D. Colon-Ramos

This study shows that PFK-1.1 dynamically forms liquid-like condensates in neurons under energy stress, revealing a new mechanism for subcellular organization.

bioRxiv · May 13, 2019Cell Biology