S. Horowitz

Reconstructing Biological Molecules with Help from Video Gamers

The paper describes how Foldit players improved protein structure models in the PDB, enhancing the output of the PDB-REDO pipeline.

G-quadruplexes rescuing protein folding

This study shows G-quadruplexes can accelerate protein folding by rescuing kinetically trapped intermediates in E. coli, improving folding quality rather than just preventing aggregation.

Why are G-quadruplexes good at preventing protein aggregation?

This study identifies structural factors that enable G-quadruplexes to prevent protein aggregation, offering insights into their role in disease prevention.

Foldamers Reveal and Validate Novel Therapeutic Targets Associated with Toxic α-Synuclein Self-Assembly

This study identifies and validates novel therapeutic targets for Parkinson's disease by analyzing α-Synuclein self-assembly using foldamers and multiple assays.

G-Quadruplexes Act as Sequence Dependent Chaperones via Protein Oligomerization

This study shows nucleic acid sequences, particularly G-quadruplexes, can act as chaperones by oligomerizing with proteins to prevent aggregation, with implications for diseases like Fragile X and ALS.

Identifying dynamic, partially occupied residues using anomalous scattering

This study presents methods to detect dynamic, partially occupied protein conformations in crystals using anomalous scattering signals with low occupancy.