Tumor-Antagonizing Fibroblasts Secrete Prolargin as Tumor Suppressor in Hepatocellular Carcinoma
B. Chiavarina, R. Ronca, Y. Otaka, R. B. Sutton, S. Rezzola, T. Yokobori, P. Chiodelli, R. Souche, A. Maraver, G. Faa, T. Oyama, S. Gofflot, A. Bellahcene, O. Detry, P. Delvenne, , A. Turtoi
The paper identifies prolargin as a tumor suppressor secreted by tumor-antagonizing fibroblasts in HCC, showing its correlation with patient outcomes and its inhibition of tumor progression.
bioRxiv · Jan 4, 2021 · PreprintCancer Biology