T. Oyama

Cancer-associated Fibroblast Spatial Heterogeneity and EMILIN1 Expression in Cancer Stroma Modulate TGF-beta Activity and CD8+ T-Cell Infiltration in Breast Cancer

This study identifies EMILIN1 as a TGF-beta inhibitor expressed in IFN-gamma CAFs that modulates TGF-beta activity and CD8+ T-cell infiltration in breast cancer.

No circadian clock-gene circuit in the generation of cellular bioluminescence rhythm of CaMV35S::PtRLUC in duckweed

The paper shows that the CaMV35S::PtRLUC bioluminescence rhythm in duckweed is not controlled by the circadian clock gene circuit, unlike the AtCCA1::LUC+ rhythm.

Circadian-period variation underlies the local adaptation of photoperiodism in the short-day plant Lemna aequinoctialis.

This study shows that variation in the circadian free-running period (FRP) correlates with adaptive photoperiodism traits in Lemna aequinoctialis, linking chronotype variation to local adaptation.

Interspecific divergence of circadian properties in duckweed plants

The paper compares circadian rhythms in duckweed species across temperature and light conditions, finding differences linked to phylogeny and morphology.

Adaptive diversification in the cellular circadian behavior of Arabidopsis leaf- and root-derived cells

This study shows that leaf- and root-derived cells of Arabidopsis have distinct circadian properties, with leaf cells showing stronger persistence against environmental fluctuations.

An endogenous basis for synchronization manners of the circadian rhythm in proliferating Lemna minor plants

This study investigates circadian rhythm synchronization in Lemna minor plants using bioluminescence reporters, revealing local coupling as the mechanism for phase pattern formation in the absence of long-distance communication.

Tumor-Antagonizing Fibroblasts Secrete Prolargin as Tumor Suppressor in Hepatocellular Carcinoma

The paper identifies prolargin as a tumor suppressor secreted by tumor-antagonizing fibroblasts in HCC, showing its correlation with patient outcomes and its inhibition of tumor progression.

Detection of uncoupled circadian rhythms in individual cells of Lemna minor using a dual-color bioluminescence monitoring system

This paper develops a dual-color bioluminescence monitoring system to observe circadian rhythms in individual Lemna minor cells, revealing uncoupling between oscillator and output.

A solvable model of entrainment ranges for the circadian rhythm under light/dark cycles

This paper develops a continuous model to analyze circadian rhythm entrainment under light/dark cycles and finds that entrainment ranges vary among organisms, with plants showing larger ranges than mammals.