Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming
D. Chondronasiou, D. Gill, L. Mosteiro, R. G. Urdinguio, A. Berenguer, M. Aguilera, S. Durand, F. Aprahamian, N. Nirmalathasan, M. Abad, D. E. Martin-Herranz, C. Stephan-Otto Attolini, N. Prats, G. Kroemer, M. F. Fraga, , M. Serrano
This study shows that a single cycle of transient OSKM expression reverses aging-related DNA methylation, transcriptional, and metabolic changes in multiple tissues of aged mice.
bioRxiv · Jan 20, 2022Cell Biology