Induction of senescence renders cancer cells highly immunogenic
I. Marin, O. Boix, A. Garcia-Garijo, i. Sirois, A. Caballe, E. Zarzuela, I. Ruano, C. Stephan-Otto Attolini, N. Prats, J. A. Lopez-Dominguez, M. Kovatcheva, E. Garralda, J. Munoz, E. Caron, M. Abad, , M. Serrano
This study shows that inducing senescence in cancer cells enhances their immunogenicity, leading to stronger anti-tumor immune responses compared to immunogenic cell death.
bioRxiv · Jun 5, 2022 · PreprintCancer Biology