Traumatic brain injury modifies adult hippocampal neural stem cell fate to promote neurogenesis at the cost of astrogliogenesis.
Pascal Bielefeld, Araks Martirosyan, Soraya Martín‐Suárez, A. Apresyan, Gideon F. Meerhoff, Francisco Pestana, Suresh Kumar Poovathingal, Niels Reijner, Winette Koning, R. A. Clement, Isa van der Veen, Enrique M. Toledo, Oliver Polzer, Irene Durá, Svetlana M. Hovhannisyan, , Carlos Patricio Fitzsimons
This study shows that traumatic brain injury shifts adult hippocampal neural stem cell fate toward neurogenesis and away from astrogliogenesis, using single-cell RNA sequencing and spatial transcriptomics.
Nature Communications · Jun 18, 2024Peer-reviewedNeuroscience