The paper identifies MIRINE, a small ORF-encoded polypeptide that promotes neuronal differentiation in vertebrate brain development by regulating the balance between proliferation and maturation.

bioRxiv · Nov 2, 2026 · PreprintBiochemistry

The Immunoregulatory Architecture of the Adult Oral Cavity

Bruno Fernandes Matuck, Khoa Huynh, Diana Pereira, Quinn T. Easter, XiuYu Zhang, Meik Kunz, Nikhil M Kumar, Aditya Pratapa, Brittany Rupp, Ameer Ghodke, Alexander V. Predeus, Alexandre Fernandes, Lili Szabó, Stefan Hartmann, Nadja Harnischfeger, , Kevin M. Byrd

This paper presents a single-cell and spatial proteotranscriptomic atlas of human oral tissues, identifying fibroblasts as key immunoregulatory hubs and revealing changes in disease states.

Cell Press Blue · Mar 23, 2026Peer-reviewedCell Biology

Traumatic brain injury modifies adult hippocampal neural stem cell fate to promote neurogenesis at the cost of astrogliogenesis.

Pascal Bielefeld, Araks Martirosyan, Soraya Martín‐Suárez, A. Apresyan, Gideon F. Meerhoff, Francisco Pestana, Suresh Kumar Poovathingal, Niels Reijner, Winette Koning, R. A. Clement, Isa van der Veen, Enrique M. Toledo, Oliver Polzer, Irene Durá, Svetlana M. Hovhannisyan, , Carlos Patricio Fitzsimons

This study shows that traumatic brain injury shifts adult hippocampal neural stem cell fate toward neurogenesis and away from astrogliogenesis, using single-cell RNA sequencing and spatial transcriptomics.

Nature Communications · Jun 18, 2024Peer-reviewedNeuroscience

A spatially resolved single cell genomic atlas of the adult human breast

Tapsi Kumar, Kevin Nee, Runmin Wei, Siyuan He, Quy Nguyen, Shanshan Bai, Kerrigan Blake, Maren Pein, Yanwen Gong, Emi Sei, Min Shan Hu, Tod D. Casasent, Aatish Thennavan, Jianzhuo Li, Tuan Tran, , Nicholas E. Navin

This paper constructs a comprehensive spatially resolved single-cell genomic atlas of the adult human breast, identifying 11 major cell types and revealing diverse immune and epithelial cell populations.

Nature · Jun 28, 2023Peer-reviewedGenomics

Highly resolved spatial transcriptomics for detection of rare events in cells

Silvia Groiss, Daniela Pabst, Cynthia Faber, Andreas Meier, Annette Bogdoll, Conny Unger, Benedikt S. Nilges, Sascha Strauß, Esther Föderl-Höbenreich, Melina Hardt, Andreas Geipel, Frank Reinecke, Christian Korfhage, Kurt Zatloukal

The paper introduces a single-cell spatial transcriptomics method called Molecular Cartography to detect rare events in host-pathogen interactions with high sensitivity and resolution.

bioRxiv · Oct 11, 2021 · PreprintMolecular Biology

Diversity and Function of Motile Ciliated Cell Types within Ependymal Lineages of the Zebrafish Brain

Percival P. D’Gama, Tao Qiu, Mehmet İlyas Coşacak, Dheeraj Rayamajhi, Ahsen Konac, Jan N. Hansen, Christa Ringers, Francisca Acuña, Subhra Prakash Hui, Emilie Willoch Olstad, Yan Ling Chong, Charlton Kang An Lim, Astha Gupta, Chee Peng Ng, Benedikt S. Nilges, , Nathalie Jurisch‐Yaksi

The paper characterizes motile ciliated cells in zebrafish brain ventricles, showing their developmental origins, functional roles in CSF flow, and impact on ventricular morphology.

Cell Reports · Oct 1, 2021Peer-reviewedNeuroscience

The translation inhibitor cycloheximide affects ribosome profiling data in a species-specific manner

Puneet Sharma, Jie Wu, Benedikt S. Nilges, Sebastian A. Leidel

This study shows that cycloheximide affects ribosome profiling data differently in yeast and human cells, suggesting that CHX may not be necessary for accurate human ribosome profiling.

Nature Communications · Aug 24, 2021Peer-reviewedMolecular Biology