Enrique M. Toledo

This study identifies SorCS2 as a regulator of Wnt signaling homeostasis by controlling Ror2 trafficking and signaling, with implications for neurodevelopment.

This study identifies perineurial cells as integrators of leptin and sympathetic outflow, showing their role in obesity protection through barrier function and beta 2 adrenergic receptor regulation.

This study develops bioengineered human skeletal muscle tissues that mature metabolically and functionally, capturing key aspects of glucose metabolism and response to exercise and pharmacological agents.

This study shows that traumatic brain injury shifts adult hippocampal neural stem cell fate toward neurogenesis and away from astrogliogenesis, using single-cell RNA sequencing and spatial transcriptomics.

The paper identifies two distinct radial glia subtypes in the developing midbrain and shows their different roles in dopaminergic neuron development using human stem cells.

This paper introduces a method to detect functional modules in single-cell RNA sequencing data by integrating with protein-protein interaction networks, revealing biology beyond differential expression analysis.

The paper identifies three radial glia types contributing to midbrain dopaminergic neurogenesis through distinct developmental signals and transcription factor networks.