Carlos Patricio Fitzsimons

The paper identifies unique transcriptional profiles of immature neurons in aged human hippocampus across healthy, Alzheimer's disease, and resilient conditions, linking them to homeostasis and cognitive resilience.

This study shows that traumatic brain injury shifts adult hippocampal neural stem cell fate toward neurogenesis and away from astrogliogenesis, using single-cell RNA sequencing and spatial transcriptomics.

This study shows that inhibiting cannabinoid type 2 receptors combined with physical exercise reduces stress-induced emotional and cognitive deficits and enhances adult hippocampal neurogenesis.

The paper identifies hippocampal reactive neural stem cells (react-NSCs) as phagocytic and immunologically active cells in two pathological models, MTLE and TBI.

This study shows that the piRNA pathway is essential for adult neurogenesis by repressing protein synthesis and cellular senescence in mouse hippocampal neural progenitor cells.