Loss of BCL-3 sensitises colorectal cancer cells to DNA damage, revealing a role for BCL-3 in double strand break repair by homologous recombination
C. Parker, A. C. Chambers, D. Flanagan, T. J. Collard, G. Ngo, D. M. Baird, P. Timms, R. G. Morgan, O. J. Sansom, A. C. Williams
This study shows that loss of BCL-3 increases DNA damage and reduces homologous recombination in colorectal cancer cells, suggesting BCL-3 as a potential target to enhance DNA damage therapy response.
bioRxiv · Aug 3, 2021 · PreprintCancer Biology