Author

A. C. Williams

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 3 Organism:mouse· 3 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

T. J. Collard· 3 shared A. K. Holt· 2 shared A. Y. Ye· 2 shared B. F. Haynes· 2 shared C. Jing· 2 shared D. N. Legge· 2 shared E. E. Vincent· 2 shared F. W. Alt· 2 shared

Activity by Year

2021-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCancer Biology

T. J. Collard

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Humanized V(D)J-rearranging and TdT-expressing Mouse Vaccine Models with Physiological HIV-1 Broadly Neutralizing Antibody Precursors

S. Luo, C. Jing, A. Y. Ye, S. Kratochvil, C. A. Cottrell, J.-H. Koo, A. C. Williams, L. V. Francisco, H. Batra, E. Lamperti, O. Kalyuzhniy, Y. Zhang, A. Barbieri, J. P. Manis, B. F. Haynes, , F. W. Alt

This paper introduces new mouse models expressing human HIV-1 broadly neutralizing antibody (bnAb) precursors with more physiological levels and diversity, enhancing vaccine research for bnAb elicitation.

Proceedings of the National Academy of Sciences · Dec 27, 2022Peer-reviewedImmunology

Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition

A. K. Holt, A. K. Najumudeen, A. J. Hoskin, D. N. Legge, E. M. H. Mortensson, D. J. Flanagan, N. Jones, M. Kollareddy, T. J. Collard, P. Timms, O. J. Sansom, A. C. Williams, E. E. Vincent

This study shows aspirin reprograms colorectal cancer cell metabolism and increases sensitivity to glutaminase inhibition, suggesting potential for improved metabolic therapies in CRC.

bioRxiv · Aug 24, 2022Cancer Biology

Humanized antibody potently neutralizes all SARS-CoV-2 variants by a novel mechanism

S. Luo, J. Zhang, A. J. B. Kreutzberger, A. Eaton, R. J. Edwards, C. Jing, H.-Q. Dai, G. D. Sempowski, K. Cronin, R. Parks, A. Y. Ye, K. Mansouri, M. Barr, N. Pishesha, A. C. Williams, , F. W. Alt

The paper describes a humanized antibody, SP1-77, that neutralizes all SARS-CoV-2 variants by blocking membrane fusion instead of ACE2 receptor binding.

bioRxiv · Jun 26, 2022 · PreprintImmunology

Identifying targetable metabolic dependencies across colorectal cancer progression

D. N. Legge, E. Stanko, A. K. Holt, C. J. Bull, T. J. Collard, M. Kollareddy, J. Bellamy, S. Groves, E. H. Ma, E. Hazelwood, D. Qualtrough, B. Amulic, K. N. Malik, A. C. Williams, N. Jones, E. E. Vincent

This study identifies asparagine synthesis as a metabolic vulnerability in late-stage colorectal cancer cells, showing that blocking asparagine synthetase inhibits their proliferation.

bioRxiv · Mar 23, 2022Cancer Biology

Loss of BCL-3 sensitises colorectal cancer cells to DNA damage, revealing a role for BCL-3 in double strand break repair by homologous recombination

C. Parker, A. C. Chambers, D. Flanagan, T. J. Collard, G. Ngo, D. M. Baird, P. Timms, R. G. Morgan, O. J. Sansom, A. C. Williams

This study shows that loss of BCL-3 increases DNA damage and reduces homologous recombination in colorectal cancer cells, suggesting BCL-3 as a potential target to enhance DNA damage therapy response.

bioRxiv · Aug 3, 2021 · PreprintCancer Biology