Author

D. Flanagan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Animal Behavior & Cognition· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:behavioral assay· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

E. Vincan· 2 shared A. C. Chambers· 1 shared A. C. Williams· 1 shared A. P. Chilver· 1 shared A. Ruszkiewicz· 1 shared B. M. Tran· 1 shared C. J. Anderson· 1 shared C. J. Pittenger· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

E. Vincan

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Prefrontal allopregnanolone mediates the adverse effects of acute stress in a mouse model of tic pathophysiology

R. Cadeddu, M. Van Zandt, K. Odeh, C. J. Anderson, D. Flanagan, P. Nordkild, C. J. Pittenger, M. Bortolato

This study shows that allopregnanolone in the prefrontal cortex mediates stress-induced worsening of tics in a mouse model of Tourette syndrome.

bioRxiv · Oct 29, 2022Animal Behavior & Cognition

Human Liver Organoids as a Patient-derived Model for HBV Infection and Cellular Response

C. K. Lim, O. Romeo, A. P. Chilver, B. M. Tran, D. Flanagan, E. N. Kirby, J. Breen, E. Vincan, N. Warner, E. M. McCartney, M. Van der Hoek, A. Ruszkiewicz, E. Tse, M. R. Beard

This paper develops a liver organoid model to study HBV infection and antiviral responses, showing it supports the full HBV lifecycle and can assess drug and immunomodulator effects.

bioRxiv · Oct 20, 2022 · PreprintMicrobiology

Loss of BCL-3 sensitises colorectal cancer cells to DNA damage, revealing a role for BCL-3 in double strand break repair by homologous recombination

C. Parker, A. C. Chambers, D. Flanagan, T. J. Collard, G. Ngo, D. M. Baird, P. Timms, R. G. Morgan, O. J. Sansom, A. C. Williams

This study shows that loss of BCL-3 increases DNA damage and reduces homologous recombination in colorectal cancer cells, suggesting BCL-3 as a potential target to enhance DNA damage therapy response.

bioRxiv · Aug 3, 2021 · PreprintCancer Biology

PI3K Activation In Neural Stem Cells Drives Tumorigenesis Which Can Be Suppressed By Targeting CREB

P. Daniel, G. Filiz, D. Brown, M. Christie, P. Waring, Y. Zhang, J. Haynes, C. Pouton, D. Flanagan, E. Vincan, T. Johns, K. Montgomery, W. Phillips, T. Mantamadiotis

This study shows that PI3K pathway activation in neural stem cells initiates tumorigenesis, and targeting CREB reduces tumor growth in a mouse model of high-grade glioma.

bioRxiv · May 30, 2017Cancer Biology