Author

A. C. Leonard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Assay:protein structure· 2 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1 Organism:plant (other)· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

T. A. Whitehead· 2 shared A. Erbse· 1 shared A. J. Friedman· 1 shared B. M. Petersen· 1 shared J. Kaar· 1 shared J. Weinstein· 1 shared M. R. Shirts· 1 shared P. J. Steiner· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBioengineering

T. A. Whitehead

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Author profile →

2 papers

Recent·Most cited

Rationalizing diverse binding mechanisms to the same protein fold: in-sights for ligand recognition and biosensor design

A. C. Leonard, A. J. Friedman, R. Chayer, B. M. Petersen, J. Kaar, M. R. Shirts, T. A. Whitehead

This study analyzes two engineered biosensors based on PYR1 to recognize different ligands, revealing binding mechanisms and computational methods for biosensor design.

bioRxiv · Mar 25, 2024Bioengineering

Stabilization of the SARS-CoV-2 Receptor Binding Domain by Protein Core Redesign and Deep Mutational Scanning

A. C. Leonard, J. Weinstein, P. J. Steiner, A. Erbse, S. J. Fleishman, T. A. Whitehead

The paper stabilizes the SARS-CoV-2 RBD using deep mutational scanning and computational design, resulting in a more thermally stable and proteolytically resistant variant.

bioRxiv · Nov 22, 2021Biochemistry