Most commonly mutated genes in High Grade Serous Ovarian Carcinoma are nonessential for ovarian surface epithelial stem cell transformation
R. J. Yamulla, S. Nalubola, A. Flesken-Nikitin, A. C. Nikitin, J. C. Schimenti
This study identifies mutation combinations critical for ovarian surface epithelial stem cell transformation in HGSOC using CRISPR mutagenesis, showing most common mutations have no effect while RB1/PTEN/TP53 disruption is essential.
bioRxiv · Jan 27, 2020Cancer Biology