Author

A. Flesken-Nikitin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6

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Research Focus:cell type annotation· 4 Research Focus:cancer & tumor microenvironment· 3 Approach:genetic perturbation / CRISPR· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2

Frequent Co-Authors

A. Y. Nikitin· 4 shared B. D. Cosgrove· 3 shared A. J. De Micheli· 2 shared D.-J. Fu· 2 shared J. C. Schimenti· 2 shared M. Bidarimath· 2 shared A. C. Nikitin· 1 shared A. K. Godwin· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersCancer Biology

A. Y. Nikitin

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6 papers

Recent·Most cited

Dysregulation of cell state dynamics during early stages of serous endometrial carcinogenesis

A. Flesken-Nikitin, M. G. Pirtz, C. S. Ashe, L. H. Ellenson, B. D. Cosgrove, A. Y. Nikitin

This study identifies 44 genes, including novel markers like OAS2 and OASL, as potential early diagnostic and prognostic markers for serous endometrial carcinoma using a mouse model and multi-omics approaches.

bioRxiv · Mar 15, 2024 · PreprintCancer Biology

Pre-ciliated tubal epithelial cells are prone to initiation of high-grade serous ovarian carcinoma

A. Flesken-Nikitin, C. Q. Ralston, D.-J. Fu, A. J. De Micheli, D. J. Phuong, B. A. Harlan, A. P. Armstrong, D. McKellar, S. Ghuwalewala, J. C. Schimenti, B. D. Cosgrove, A. Y. Nikitin

The paper identifies pre-ciliated tubal epithelial cells as a cancer-prone state in high-grade serous ovarian carcinoma by analyzing mouse uterine tube cell states and lineage dynamics.

bioRxiv · Dec 12, 2023Cancer Biology

PAX8 expressing epithelial cells are a cancer-prone source of clonal cyclical regeneration of endometrial epithelium

D.-J. Fu, A. J. De Micheli, M. Bidarimath, L. Ellenson, B. D. Cosgrove, A. Flesken-Nikitin, A. Nikitin

The paper was withdrawn due to authorship issues and should not be cited.

bioRxiv · Jun 7, 2023Cancer Biology

Most commonly mutated genes in High Grade Serous Ovarian Carcinoma are nonessential for ovarian surface epithelial stem cell transformation

R. J. Yamulla, S. Nalubola, A. Flesken-Nikitin, A. C. Nikitin, J. C. Schimenti

This study identifies mutation combinations critical for ovarian surface epithelial stem cell transformation in HGSOC using CRISPR mutagenesis, showing most common mutations have no effect while RB1/PTEN/TP53 disruption is essential.

bioRxiv · Jan 27, 2020Cancer Biology

WNT and inflammatory signaling distinguish human Fallopian tube epithelial cell populations

I. M. Rose, M. Bidarimath, A. Webster, A. K. Godwin, A. Flesken-Nikitin, A. Y. Nikitin

This study identifies molecular differences between proximal and distal human Fallopian tube epithelial cells, showing increased WNT and inflammatory signaling in distal cells associated with ovarian cancer susceptibility.

bioRxiv · Jan 15, 2020Cancer Biology

Membrane metalloendopeptidase suppresses prostate carcinogenesis by attenuating effects of gastrin-releasing peptide on stem/progenitor cells

C.-Y. Cheng, Z. Zhou, M. Stone, B. Lu, A. Flesken-Nikitin, D. M. Nanus, A. Y. Nikitin

This study shows MME suppresses prostate cancer by inhibiting GRP/GRPR signaling in stem/progenitor cells, and identifies GRPR as a therapeutic target in MME-low cancers.

bioRxiv · Dec 23, 2019Cancer Biology