J. C. Schimenti

Scalable primordial germ cell-like-cell platform for functional genomics identifies epigenetic fertility modifiers

This paper develops a scalable method to generate PGC-like cells and uses it to identify epigenetic factors affecting germline development.

Pre-ciliated tubal epithelial cells are prone to initiation of high-grade serous ovarian carcinoma

The paper identifies pre-ciliated tubal epithelial cells as a cancer-prone state in high-grade serous ovarian carcinoma by analyzing mouse uterine tube cell states and lineage dynamics.

Imaging optically thick tissues simply and reproducibly: a practical guide to Lightsheet Macroscopy

The paper provides practical guidelines for mounting and imaging cleared tissues using lightsheet microscopy in standardized optical cuvettes, improving reproducibility and cost-effectiveness.

A Reporter Mouse for In Vivo Detection of DNA Damage in Embryonic Germ Cells

This paper develops a transgenic mouse reporter that detects DNA damage in embryonic germ cells using a 53BP1-mCherry fusion protein under the Oct4{Delta}PE promoter.

Most commonly mutated genes in High Grade Serous Ovarian Carcinoma are nonessential for ovarian surface epithelial stem cell transformation

This study identifies mutation combinations critical for ovarian surface epithelial stem cell transformation in HGSOC using CRISPR mutagenesis, showing most common mutations have no effect while RB1/PTEN/TP53 disruption is essential.

Pharmacological inhibition of the DNA damage checkpoint prevents radiation-induced oocyte death

Pharmacological inhibition of CHK2 protects oocytes from radiation-induced death, preserving fertility and ovarian function in mice.