Long-term retention of antigens in germinal centres is controlled by the spatial organisation of the follicular dendritic cell network
A. Martinez-Riano, S. Wang, S. Boeing, S. Minoughan, A. Casal, K. M. Spillane, B. Ludewig, P. Tolar
The paper shows that follicular dendritic cells (FDCs) in germinal centers (GCs) have distinct spatial organization that controls antigen retention, with central FDCs acting as long-term antigen reservoirs.
bioRxiv · Sep 6, 2022 · PreprintImmunology