Author

P. Tolar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Organism:mouse· 5 Approach:experimental assay· 4 Approach:genetic perturbation / CRISPR· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Assay:imaging· 2 Assay:proteomics· 2

Frequent Co-Authors

L. Wasim· 3 shared D. Malinova· 2 shared D. P. Calado· 2 shared L. Zhang· 2 shared N. Engels· 2 shared R. Newman· 2 shared S. Minoughan· 2 shared A. Camara· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersImmunology

L. Wasim

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Mutations in the IgG B cell receptor associated with class-switched B cell lymphomas

L. Wasim, S. W. T. Chu, B. Sale, L. Pickard, S. Leonard, L. Zhang, H. Tolarova, Z. S. Tean, N. Engels, D. P. Calado, K. Tarte, J. Okosun, F. Forconi, P. Tolar

This study identifies mutations in the IgG heavy chain in follicular lymphoma and EZB DLBCL that enhance BCR signalling and oncogenicity by disrupting the IgG intracellular tail.

bioRxiv · Apr 12, 2024 · PreprintImmunology

Regulation of BCR-mediated Ca2+ mobilization by MIZ1-TIMBIM4 safeguards IgG1+ GC B cell positive selection

L. Zhang, A. Toboso-Navasa, A. Gunawan, A. Camara, R. Nakagawa, K. Finsterbusch, P. Chakravarty, R. Newman, Y. Zhang, M. Eilers, A. Wack, P. Tolar, K.-M. Toellner, D. P. Calado

This study identifies MIZ1-TMBIM4 as a mechanism safeguarding IgG1+ GC B cell positive selection by regulating Ca2+ mobilization and preventing mitochondrial dysfunction.

bioRxiv · Jul 18, 2023 · PreprintImmunology

Long-term retention of antigens in germinal centres is controlled by the spatial organisation of the follicular dendritic cell network

A. Martinez-Riano, S. Wang, S. Boeing, S. Minoughan, A. Casal, K. M. Spillane, B. Ludewig, P. Tolar

The paper shows that follicular dendritic cells (FDCs) in germinal centers (GCs) have distinct spatial organization that controls antigen retention, with central FDCs acting as long-term antigen reservoirs.

bioRxiv · Sep 6, 2022 · PreprintImmunology

Digital holography-based 3D particle localisation for single molecule tweezer techniques

J. Flewellen, S. Minoughan, I. Llorente Garcia, P. Tolar

This paper introduces a 3D imaging technique for tracking microscopic objects in fluid environments, demonstrating improved precision and speed compared to existing methods.

bioRxiv · May 3, 2022Biophysics

Genome-wide screens identify calcium signaling as a key regulator of IgE+ plasma celldifferentiation and survival

R. Newman, P. Tolar

This study identifies calcium signaling as a key regulator of IgE+ plasma cell differentiation and survival through whole-genome CRISPR screening.

bioRxiv · Mar 2, 2021 · PreprintImmunology

Endophilin A2 regulates B cell protein trafficking and humoral responses

D. Malinova, L. Wasim, N. Engels, P. Tolar

This study identifies endophilin A2 as essential for B cell endosomal trafficking, germinal center responses, and high-affinity IgG production through clathrin-independent mechanisms.

bioRxiv · Apr 20, 2020 · PreprintImmunology

B cells extract antigens using Arp2/3-generated actin foci interspersed with linear filaments

S. I. Roper, L. Wasim, D. Malinova, M. Way, S. Cox, P. Tolar

This study identifies the role of Arp2/3-generated actin foci and formin-produced linear filaments in B cell antigen extraction through immune synapse mechanics.

bioRxiv · Oct 4, 2019Immunology