A. Martinez-Riano

Long-term retention of antigens in germinal centres is controlled by the spatial organisation of the follicular dendritic cell network

The paper shows that follicular dendritic cells (FDCs) in germinal centers (GCs) have distinct spatial organization that controls antigen retention, with central FDCs acting as long-term antigen reservoirs.

Recreation of an antigen-driven germinal center in vitro by providing B cells with phagocytic antigen

This study recreates an antigen-driven germinal center in vitro using B and T cells, demonstrating the generation of high-affinity immunoglobulins through phagocytic antigen uptake.