Author

A. Castela

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Coomans de Brachene· 2 shared D. L. Eizirik· 2 shared L. Marselli· 2 shared M. I. Alvelos· 2 shared P. Marchetti· 2 shared A. C. Title· 1 shared A. Op de Beeck· 1 shared A. Roca Rivada· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersPhysiology

A. Coomans de Brachene

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice

F. Syed, O. Ballew, C.-C. Lee, J. Rana, P. Krishnan, A. Castela, S. A. Weaver, N. S. Chalasani, S. F. Thomaidou, S. Demine, G. Chang, A. Coomans de Brachene, M. I. Alvelos, L. Marselli, K. Orr, , C. Evans-Molina

This study shows that TYK2 inhibitors reduce islet inflammation and delay type 1 diabetes onset in mice by modulating immune and endocrine responses.

bioRxiv · Mar 20, 2024Physiology

Interferons are the key cytokines acting on pancreatic islets in type 1 diabetes

A. Coomans de Brachene, M. I. Alvelos, F. Szymczak, P. L. Zimath, A. Castela, B. Marmontel de Souza, A. Roca Rivada, S. Marin-Canas, X. Yi, A. Op de Beeck, N. G. Morgan, S. Sonntag, S. Jawurek, A. C. Title, B. Yesildag, , D. L. Eizirik

This study identifies IFN and IFNγ as key cytokines affecting pancreatic beta cells in type 1 diabetes through RNA-sequencing analysis and comparison with T1D islet signatures.

bioRxiv · Jun 29, 2023Immunology