C. Evans-Molina

Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice

This study shows that TYK2 inhibitors reduce islet inflammation and delay type 1 diabetes onset in mice by modulating immune and endocrine responses.

Histone Deacetylase Inhibitors Prevent Cytokine-Induced β Cell Dysfunction Through Restoration of Stromal Interaction Molecule 1 Expression and Activation of Store-Operated Calcium Entry

This study shows that HDI sodium butyrate improves β cell function and calcium signaling in diabetes by restoring STIM1 and SOCE, and inhibiting GSK-3 through AKT.

β Cell microRNAs Function as Molecular Hubs of Type 1 Diabetes Pathogenesis and as Biomarkers of Diabetes Risk

The paper identifies miRNAs in human islets and EVs that change under inflammatory conditions and can serve as biomarkers for type 1 diabetes risk.

Stromal Interaction Molecule 1 Maintains β Cell Identity and Function in Female Mice through Preservation of G Protein-Coupled Estrogen Receptor 1 Signaling

This study shows that STIM1 maintains β cell identity and function in female mice by preserving GPER1 signaling, which is disrupted by high-fat diet.

SERCA2 regulates proinsulin processing and processing enzyme maturation in the pancreatic β cell

This study identifies SERCA2 as a regulator of proinsulin processing and processing enzyme maturation in pancreatic β cells, linking ER Ca2+ levels to impaired glucose tolerance in diabetes.

A discovery-based proteomics approach identifies protein disulfide isomerase (PDIA1) as a biomarker of β cell stress in type 1 diabetes

The paper identifies PDIA1 as a biomarker of β cell stress in type 1 diabetes using proteomics and validation in mouse models and human samples.

Loss of Secretory Pathway Ca2+ ATPase (SPCA1) Impairs Insulin Secretion and Reduces Autophagy in the Pancreatic Islet

This study shows that loss of SPCA1 in pancreatic beta cells reduces Golgi Ca2+ levels, impairs glucose-stimulated insulin secretion, and decreases autophagy.

Carbonyl Post-Translational Modification Associated with Early Onset Type 1 Diabetes Autoimmunity

The paper identifies carbonylated P4Hb as an autoantigen in type 1 diabetes, detected before hyperglycemia in NOD mice and early human disease.

High resolution analysis of the cytosolic Ca2+ events in beta cell collectives in situ

This study measures Ca2+ dynamics in beta cell collectives using high-resolution imaging and a new computational framework, revealing three modes of Ca2+ event durations and the role of intracellular Ca2+ receptors.

ACE2 and SARS-CoV-2 Expression in the Normal and COVID-19 Pancreas

This study examines ACE2 and SARS-CoV-2 expression in normal and COVID-19 pancreas tissues, finding prominent ACE2 expression in ductal epithelium and microvasculature, with limited endocrine cell expression and no strong evidence of SARS-CoV-2 infection of endocrine cells.

Abnormalities in Proinsulin Processing in Islets from Individuals with Longstanding T1D

The paper investigates proinsulin processing abnormalities in T1D islets, finding reduced processing enzymes and cytokine-induced expression changes.