Author

S. A. Weaver

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Physiology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:mouse· 4 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. Evans-Molina· 4 shared C.-C. Lee· 3 shared P. Krishnan· 3 shared T. M. Kono· 3 shared F. Syed· 2 shared G. Chang· 2 shared J. Liu· 2 shared R. N. Bone· 2 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersPhysiology

C. Evans-Molina

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice

F. Syed, O. Ballew, C.-C. Lee, J. Rana, P. Krishnan, A. Castela, S. A. Weaver, N. S. Chalasani, S. F. Thomaidou, S. Demine, G. Chang, A. Coomans de Brachene, M. I. Alvelos, L. Marselli, K. Orr, , C. Evans-Molina

This study shows that TYK2 inhibitors reduce islet inflammation and delay type 1 diabetes onset in mice by modulating immune and endocrine responses.

bioRxiv · Mar 20, 2024Physiology

Histone Deacetylase Inhibitors Prevent Cytokine-Induced β Cell Dysfunction Through Restoration of Stromal Interaction Molecule 1 Expression and Activation of Store-Operated Calcium Entry

C.-C. Lee, T. M. Kono, F. Syed, S. A. Weaver, P. Sohn, W. Wu, G. Chang, J. Liu, M. S. Rupnik, C. Evans-Molina

This study shows that HDI sodium butyrate improves β cell function and calcium signaling in diabetes by restoring STIM1 and SOCE, and inhibiting GSK-3 through AKT.

bioRxiv · Dec 6, 2023 · PreprintPhysiology

SERCA2 regulates proinsulin processing and processing enzyme maturation in the pancreatic β cell

H. Iida, T. M. Kono, C.-C. Lee, P. Krishnan, M. C. Arvin, S. A. Weaver, T. S. Jarvela, R. N. Bone, X. Tong, P. Arvan, I. Lindberg, C. Evans-Molina

This study identifies SERCA2 as a regulator of proinsulin processing and processing enzyme maturation in pancreatic β cells, linking ER Ca2+ levels to impaired glucose tolerance in diabetes.

bioRxiv · Jun 13, 2022 · PreprintPhysiology

Loss of Secretory Pathway Ca2+ ATPase (SPCA1) Impairs Insulin Secretion and Reduces Autophagy in the Pancreatic Islet

R. N. Bone, X. Tong, S. A. Weaver, C. Muralidharan, P. Krishnan, T. M. Kono, C. Evans-Molina

This study shows that loss of SPCA1 in pancreatic beta cells reduces Golgi Ca2+ levels, impairs glucose-stimulated insulin secretion, and decreases autophagy.

bioRxiv · Aug 30, 2021 · PreprintCell Biology