An evolutionary divergent thermodynamic brake in ZAP-70 finetunes the kinetic proofreading in T cell
K. Gangopadhyay, A. Roy, A. Chandradasan, S. Roy, O. Debnath, S. SenGupta, S. Chowdhury, D. Das, R. Das
This study identifies a thermodynamic brake in ZAP-70 that regulates T cell signaling kinetics and ligand selectivity, with evolutionary implications for immune system divergence.
bioRxiv · Nov 9, 2021Biochemistry