Author

K. Gangopadhyay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

O. Debnath· 2 shared R. Das· 2 shared S. Chowdhury· 2 shared S. Roy· 2 shared A. Chandradasan· 1 shared A. Ghosh· 1 shared A. Roy· 1 shared B. Manna· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBiochemistry

O. Debnath

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2 papers

Recent·Most cited

BiochemistrybioRxivNov 9, 2021

An evolutionary divergent thermodynamic brake in ZAP-70 finetunes the kinetic proofreading in T cell

K. Gangopadhyay, A. Roy, A. Chandradasan…·R. Das

This study identifies a thermodynamic brake in ZAP-70 that regulates T cell signaling kinetics and ligand selectivity, with evolutionary implications for immune system divergence.

DOI 10.1016/j.jbc.2022.102376

humanstatistical model

𝕏 PostBluesky

BiochemistrybioRxivNov 15, 2019

An allosteric hot-spot in the tandem-SH2 domain of ZAP-70 regulates T-cell signaling

K. Gangopadhyay, B. Manna, S. Roy…·R. Das

This paper identifies an allosteric hot-spot in ZAP-70's tandem-SH2 domain that regulates T-cell signaling by enabling cooperative ligand binding, with mutations disrupting this process and causing autoimmune arthritis.

DOI 10.1042/bcj20190879

mouseproteomics

𝕏 PostBluesky