Author

O. Debnath

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

C. Conrad· 2 shared C.-S. Leonhardt· 2 shared F. W. Ten· 2 shared J. Jabs· 2 shared K. Gangopadhyay· 2 shared N. Ishaque· 2 shared O. Strobel· 2 shared R. Das· 2 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

C. Conrad

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4 papers

Recent·Most cited

An evolutionary divergent thermodynamic brake in ZAP-70 finetunes the kinetic proofreading in T cell

K. Gangopadhyay, A. Roy, A. Chandradasan, S. Roy, O. Debnath, S. SenGupta, S. Chowdhury, D. Das, R. Das

This study identifies a thermodynamic brake in ZAP-70 that regulates T cell signaling kinetics and ligand selectivity, with evolutionary implications for immune system divergence.

bioRxiv · Nov 9, 2021Biochemistry

Deep molecular characterization linked to drug response profiling of pancreatic ductal adenocarcinoma using patient-derived organoids.

S. Le Blanc, N. Ishaque, J. Jabs, T. Bauer, S. Schuth, Q. Hu, O. Debnath, F. W. Ten, C.-S. Leonhardt, A.-K. König, M. Bieg, C. Eckert, M. M. Gaida, M. Volkmar, D. Hübschmann, , O. Strobel

This study uses patient-derived PDAC organoids to integrate genomic, transcriptomic, and drug response data, identifying novel biomarkers and resistance mechanisms for personalized treatment.

bioRxiv · Aug 26, 2021 · PreprintCancer Biology

Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy

T. G. Krieger, S. LeBlanc-Soto, J. Jabs, F. W. Ten, N. Ishaque, K. Jechow, O. Debnath, C.-S. Leonhardt, A. Giri, R. Eils, O. Strobel, C. Conrad

The paper uses single-cell RNA sequencing to analyze PDAC organoids and identifies conserved cell states and a differentiation hierarchy linked to tumor subtypes.

bioRxiv · Aug 23, 2020Cancer Biology

An allosteric hot-spot in the tandem-SH2 domain of ZAP-70 regulates T-cell signaling

K. Gangopadhyay, B. Manna, S. Roy, O. Debnath, S. Kumari, S. Chowdhury, A. Ghosh, R. Das

This paper identifies an allosteric hot-spot in ZAP-70's tandem-SH2 domain that regulates T-cell signaling by enabling cooperative ligand binding, with mutations disrupting this process and causing autoimmune arthritis.

bioRxiv · Nov 15, 2019Biochemistry